What we do
Cancer cells exhibit altered transcriptional profiles when compared to their tissue of origin. Genetic alterations participate in promoting defective transcription, however they don't explain the full spectrum of aberrations found in malignant tissues. Gene expression is also controlled via modifications of the chromatin landscape including DNA methylation, histone modifications and chromatin remodelling. Our objective is to characterize the role of the chromatin landscape in oncogenesis and to understand how cancer cells reprogram the chromatin landscape to stop the treatment from working.
We have used breast cancer models to demonstrate that epigenetic reprogramming of the chromatin landscape promotes the expression of genes directly related to resistance to endocrine therapies. We can create epigenomic maps to study the regulatory networks of cancer cells and determine how these networks respond to therapies. Ultimately, we want to exploit epigenetic mapping to identify drug-responsive targets, biomarkers and develop novel compounds to interfere with reprogramming.
We are also interested in understanding the extent of interactions existing between genetic and epigenetic alterations. It is likely that cancer cells exploit both genetic and epigenetic mutations to promote proliferation, adaptation and invasion.
What’s going on
News from our lab
The Magnani lab will be present at the Hormone-Dependent Cancers Conference in Maine (USA). Dr. Magnani and 2 PhD students, […]
Congratulation to our Ph.D. student Ylenia Perone for having well presented our research in art at the Imperial College Summer […]
Well done Darren for your achievement!! You did a great job during the last, almost 4 years. You would like […]
New facts from the world
A light-hearted but insightful satire of why you should be careful of getting your science from the press. Most of […]
Under the guise of humour, Deadpool invokes women to perform self-examination, and in a short timeslot explains why it […]
Promising tool aimed toward the goal of functionally annotating non-coding DNA. It could become a mainstaple for laboratories dedicated to […]