What we do

Cancer cells exhibit altered transcriptional profiles when compared to their tissue of origin. Genetic alterations participate in promoting defective transcription, however they don't explain the full spectrum of aberrations found in malignant tissues. Gene expression is also controlled via modifications of the chromatin landscape including DNA methylation, histone modifications and chromatin remodelling. Our objective is to characterize the role of the chromatin landscape in oncogenesis and to understand how cancer cells reprogram the chromatin landscape to stop the treatment from working.

We have used breast cancer models to demonstrate that epigenetic reprogramming of the chromatin landscape promotes the expression of genes directly related to resistance to endocrine therapies. We can create epigenomic maps to study the regulatory networks of cancer cells and determine how these networks respond to therapies. Ultimately, we want to exploit epigenetic mapping to identify drug-responsive targets, biomarkers and develop novel compounds to interfere with reprogramming.

We are also interested in understanding the extent of interactions existing between genetic and epigenetic alterations. It is likely that cancer cells exploit both genetic and epigenetic mutations to promote proliferation, adaptation and invasion. 


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News from our lab

Magnani Lab will be at the Gordon Research Conference at Sunday River Newry in US

The Magnani lab will be present at the  Hormone-Dependent Cancers Conference in Maine (USA). Dr. Magnani and 2 PhD students, […]

Our artistic taste has been awarded by Imperial College

Congratulation to our Ph.D. student Ylenia Perone for having well presented our research in art at the Imperial College Summer […]

Congratulation to Dr. Darren K Patten for obtaining the title of P.hD.

Well done Darren for your achievement!! You did a great job during the last, almost 4 years. You would like […]

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New facts from the world

Science reports in press, so frustrating!!

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Please, do not forget self examination!!

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DeepSEA a new powerful tool able to predict non-coding DNA

Promising tool aimed toward the goal of functionally annotating non-coding DNA. It could become a mainstaple for laboratories dedicated to […]

Latest scientific discoveries