What we do


Cancer cells exhibit altered transcriptional profiles when compared to their tissue of origin. Genetic alterations participate in promoting defective transcription, however they don't explain the full spectrum of aberrations found in malignant tissues. Gene expression is also controlled via modifications of the chromatin landscape including DNA methylation, histone modifications and chromatin remodelling. Our objective is to characterize the role of the chromatin landscape in oncogenesis and to understand how cancer cells reprogram the chromatin landscape to stop the treatment from working.

We have used breast cancer models to demonstrate that epigenetic reprogramming of the chromatin landscape promotes the expression of genes directly related to resistance to endocrine therapies. We can create epigenomic maps to study the regulatory networks of cancer cells and determine how these networks respond to therapies. Ultimately, we want to exploit epigenetic mapping to identify drug-responsive targets, biomarkers and develop novel compounds to interfere with reprogramming.

We are also interested in understanding the extent of interactions existing between genetic and epigenetic alterations. It is likely that cancer cells exploit both genetic and epigenetic mutations to promote proliferation, adaptation and invasion. 

 

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News from our lab

Our artistic taste has been awarded by Imperial College

Congratulation to our Ph.D. student Ylenia Perone for having well presented our research in art at the Imperial College Summer […]

Congratulation to Dr. Darren K Patten for obtaining the title of P.hD.

Well done Darren for your achievement!! You did a great job during the last, almost 4 years. You would like […]

Our lab at GRC of Cancer Genetics and Epigenetics 2017

Luca Magnani and 2 of our Ph.D. students, Darren K Patten and Giacomo Corleone, presented the new results of our […]

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Science reports in press, so frustrating!!

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DeepSEA a new powerful tool able to predict non-coding DNA

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Latest scientific discoveries