Inert and repressed DNA can switch to an active function in cancer

Posted on Posted in lab

In 2015, we also collaborated with other colleagues in identifying a novel role for a protein called LMTK3. Normally, LMTK3 functions by altering other proteins (adding phosphorylation residues on them) and normally activate them.
Using our expertise in epigenomics, we found that LMTK3 is bound at DNA regions normally localised near the periphery of the nucleus. These regions are typically inert and repressed. Thus, LMTK3 can function as a scaffolding protein linking epigenetic modifications such a methylation of lysine 9 on histone 3 to
topological information (where the DNA should sit within the three-dimensional nucleus).

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