Notch signalling is important for several physiological process but is also central to the development of endocrine therapy resistance. Our group found that
in breast cancer cells resistant to drugs, Notch can be hyper-activated indirectly by increasing it’s processing. Notch proteins live on the cellular membrane but need to travel to the nucleus to bind
DNA and promote transcription. Upregulation of DMXL2 improves Notch travelling to the nucleus thus increasing the transcription of genes involved in drug resistance.