Selected publications

Harrod A, Fulton J, Nguyen VTM, Periyasamy M, Ramos-Garcia L, Lai C-F, Metodieva G, de Giorgio A, Williams RL, Santos DB, Gomez PJ, Lin M-L, Metodiev MV, Stebbing J, Castellano L, Magnani L, Coombes RC, Buluwela L, Ali S., 2017, Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancerONCOGENE, Vol: 36, Pages: 2286-2296, ISSN: 0950-92


Magnani L, Frige G, Gadaleta RM, Corleone G, Fabris S, Kempe H, Verschure PJ, Barozzi I, Vircillo V, Hong S-P, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci Set al., 2017, Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ER alpha metastatic breast cancerNATURE GENETICS, Vol: 49, Pages: 444-450, ISSN: 1061-4036


Bhat-Nakshatri P, Goswami CP, Badve S, Magnani L, Lupien M, Nakshatri Het al., 2016, Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast CancerCANCER RESEARCH, Vol: 76, Pages: 3989-4001, ISSN: 0008-5472


Chen X, Jung J-G, Shajahan-Haq AN, Clarke R, Shih I-M, Wang Y, Magnani L, Wang T-L, Xuan J et al., 2016, ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profilesNUCLEIC ACIDS RESEARCH, Vol: 44, ISSN: 0305-1048

 Hong SP, Lombardo Y, Corleone G, Coombes CR, Magnani L et al., 2016, Epigenetic plasticity identifies seed breast cancer cells driving drug resistance and metastatic progression, UK Breast Cancer Research Symposium, Publisher: SPRINGER, Pages: 191-191, ISSN: 0167-6806


Menyhart O, Harami-Papp H, Sukumar S, Schaefer R, Magnani L, de Barrios O, Gyorffy B et al., 2016, Guidelines for the selection of functional assays to evaluate the hallmarks of cancerBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, Vol: 1866, Pages: 300-319, ISSN: 0304-419X


Patel H, Abduljabbar R, Lai C-F, Periyasamy M, Harrod A, Gemma C, Steel JH, Patel N, Busonero C, Jerjees D, Remenyi J, Smith S, Gomm JJ, Magnani L, Gyorffy B, Jones LJ, Fuller-Pace F, Shousha S, Buluwela L, Rakha EA, Ellis IO, Coombes RC, Ali S et al., 2016, Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast CancerCLINICAL CANCER RESEARCH, Vol: 22, Pages: 5929-5938, ISSN: 1078-0432


Patel H, Abduljabbar R, Lai CF, Periyasamy M, Harrod A, Gemma C, Steel JH, Patel N, Busonero C, Jerjees D, Remenyi J, Smith S, Gomm JJ, Magnani L, Győrffy B, Jones LJ, Fuller-Pace F, Shousha S, Buluwela L, Rakha EA, Ellis IO, Coombes RC, Ali S et al., 2016, Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer.Clin Cancer Res, Vol: 22, Pages: 5929-5938, ISSN: 1078-0432


Perone Y, Magnani L, 2016, Going off the grid: ER alpha breast cancer beyond estradiolJOURNAL OF MOLECULAR ENDOCRINOLOGY, Vol: 57, Pages: F1-F5, ISSN: 0952-5041


Zhang Y, Clausmeyer J, Babakinejad B, Cordoba AL, Ali T, Shevchuk A, Takahashi Y, Novak P, Edwards C, Lab M, Gopal S, Chiappini C, Anand U, Magnani L, Coombes RC, Gorelik J, Matsue T, Schuhmann W, Klenerman D, Sviderskaya EV, Korchev Y et al., 2016, Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell AnalysisACS NANO, Vol: 10, Pages: 3214-3221, ISSN: 1936-0851


Faronato M, Nguyen VTM, Patten DK, Lombardo Y, Steel JH, Patel N, Woodley L, Shousha S, Pruneri G, Coombes RC, Magnani L et al., 2015, DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through notch hyper-activationONCOTARGET, Vol: 6, Pages: 22467-22479, ISSN: 1949-255

 Magnani L, Patten DK, Nguyen VTM, Hong S-P, Steel JH, Patel N, Lombardo Y, Faronato M, Gomes AR, Woodley L, Page K, Guttery D, Primrose L, Garcia DF, Shaw J, Viola P, Green A, Nolan C, Ellis IO, Rakha EA, Shousha S, Lam EW-F, Gyorffy B, Lupien M, Coombes RC et al., 2015, The pioneer factor PBX1 is a novel driver of metastatic progression in ER’-positive breast cancerONCOTARGET, Vol: 6, Pages: 21878-21891, ISSN: 1949-2553  Nakshatri H, Goswami C, Badve S, Magnani L, Lupien M, Bhat-Nakshatri P et al., 2015, Divergent activation of AKT1 and AKT2 isoforms downstream of PI3K mutation impacts response of breast cancer cells to estradiol and PI3K inhibitors, 37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472


Nguyen VTM, Barozzi I, Faronato M, Lombardo Y, Steel JH, Patel N, Darbre P, Castellano L, Gyorffy B, Woodley L, Meira A, Patten DK, Vircillo V, Periyasamy M, Ali S, Frige G, Minucci S, Coombes RC, Magnani L et al., 2015, Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasionNATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723


Okamoto OK, Matheu A, Magnani L, 2015, Stem Cells in Translational Cancer ResearchSTEM CELLS INTERNATIONAL, ISSN: 1687-966X


Periyasamy M, Patel H, Lai C-F, Nguyen VTM, Nevedomskaya E, Harrod A, Russell R, Remenyi J, Ochocka AM, Thomas RS, Fuller-Pace F, Gyorffy B, Caldas C, Navaratnam N, Carroll JS, Zwart W, Coombes RC, Magnani L, Buluwela L, Ali S et al., 2015, APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast CancerCELL REPORTS, Vol: 13, Pages: 108-121, ISSN: 2211-1247


Varghese V, Magnani L, Harada N, Eric LW, Kenny L et al., 2015, Inhibition of FOXM1 by thiostrepton increases sensitivity to 5-fluorouracil (5-FU) by downregulating thymidylate synthase (TS) in colorectal cancer, AACR Precision Medicine Conference on Drug Sensitivity and Resistance – Improving Cancer Therapy, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 1078-0432


Xu Y, Zhang H, Van TMN, Angelopoulos N, Nunes J, Reid A, Buluwela L, Magnani L, Stebbing J, Giamas G et al., 2015, LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancerCell Reports, Vol: 12, Pages: 837-849, ISSN: 2211-1247


Bianco S, Brunelle M, Jangal M, Magnani L, Gevry N et al., 2014, LRH-1 Governs Vital Transcriptional Programs in Endocrine-Sensitive and -Resistant Breast Cancer CellsCANCER RESEARCH, Vol: 74, Pages: 2015-2025, ISSN: 0008-5472


Brown R, Curry E, Magnani L, Wilhelm-Benartzi CS, Borley J et al., 2014, Poised epigenetic states and acquired drug resistance in cancerNATURE REVIEWS CANCER, Vol: 14, Pages: 747-753, ISSN: 1474-175X


Gadaleta RM, Magnani L, 2014, Nuclear receptors and chromatin: an inducible coupleJOURNAL OF MOLECULAR ENDOCRINOLOGY, Vol: 52, Pages: R137-R149, ISSN: 0952-5041


Jangal M, Couture J-P, Bianco S, Magnani L, Mohammed H, Gevry N et al., 2014, The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor alpha target genesNUCLEIC ACIDS RESEARCH, Vol: 42, Pages: 11339-11348, ISSN: 0305-1048


Lombardo Y, Faronato M, Filipovic A, Vircillo V, Magnani L, Coombes RC et al., 2014, Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cellsBREAST CANCER RESEARCH, Vol: 16, ISSN: 1465-542X


Magnani L, 2014, Epigenetic engineering and the art of epigenetic manipulationGENOME BIOLOGY, Vol: 15, ISSN: 1465-6906


Magnani L, Lupien M, 2014, Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling.Mol Cell Endocrinol, Vol: 382, Pages: 633-641


Varghese V, Magnani L, Harada N, Mauri FA, Lam EW, Kenny LM et al., 2014, Forkhead box transcription factor M1 (FOXM1) plays a critical role in colorectal cancer resistance by regulating thymidylate synthase (TS), 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472


Magnani L, Stoeck A, Zhang X, Lánczky A, Mirabella AC, Wang TL, Gyorffy B, Lupien M et al., 2013, Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer.Proc Natl Acad Sci U S A, Vol: 110, Pages: E1490-E1499


Magnani L, Brunelle M, Gévry N, Lupien M et al., 2012, Chromatin landscape and endocrine response in breast cancer.Epigenomics, Vol: 4, Pages: 675-683


Thiaville MM, Stoeck A, Chen L, Wu RC, Magnani L, Oidtman J, Shih IEM, Lupien M, Wang TL et al., 2012, Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites., PLoS One, Vol: 7